This review highlights liquid chromatography in conjunction with mass spectroscopy (LC-MS) also the brief overview on development of its interfaces, mass analyzers are discussed. The presented report touches applications of LC-MS to pharmaceutical quantitative analysis in various areas like drug discovery, metabolism studies, analysis and identification of impurities and degradation products in pharmaceuticals. Presented report also details working and instrumentation related aspects of hyphenated technology, liquid chromatography in conjunction with nuclear magnetic resonance spectroscopy (LC-NMR). The report addresses the experimental setup and major contribution of LC-NMR to various areas in pharmaceutical analysis in fields like drug metabolism and their contribution to studies to natural products is also discussed.
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